{"id":2455,"date":"2025-11-07T09:00:13","date_gmt":"2025-11-07T09:00:13","guid":{"rendered":"https:\/\/www.lunit.io\/en\/?post_type=media-hub&p=2455"},"modified":"2025-11-07T14:11:23","modified_gmt":"2025-11-07T14:11:23","slug":"lunit-ai-maps-the-tumor-immune-landscape-to-predict-immunotherapy-response-and-discover-new-antibody-targets-at-sitc-2025","status":"publish","type":"media-hub","link":"https:\/\/lunit.supremeclients.com\/en\/media-hub\/lunit-ai-maps-the-tumor-immune-landscape-to-predict-immunotherapy-response-and-discover-new-antibody-targets-at-sitc-2025\/","title":{"rendered":"Lunit AI Maps the Tumor-Immune Landscape to Predict Immunotherapy Response and Discover New Antibody Targets at SITC 2025"},"content":{"rendered":"

Studies reveal how the Lunit SCOPE\u00ae suite identifies immunotherapy-responsive subtypes, standardizes immune phenotyping, and accelerates antibody-based target discovery<\/em><\/strong><\/p>\n

\"\"<\/p>\n

SEOUL, South Korea, November 7, 2025<\/strong> \u2014 Lunit (KRX:328130.KQ), a leading provider of AI for cancer diagnostics and precision oncology, today announced the presentation of three studies at the Society for Immunotherapy of Cancer (SITC) 40th Annual Meeting, taking place November 5-9 in Maryland, U.S. The findings highlight how Lunit\u2019s AI-powered digital pathology technologies\u2014Lunit SCOPE IO\u00ae and Lunit SCOPE\u00ae uIHC\u2014can advance precision oncology by uncovering predictive immune signatures and guiding antibody-based drug development.<\/p>\n

Lunit and CellCarta presented a comparative analysis demonstrating that AI can standardize tumor immune phenotyping across multiple cancer types, including non-small cell lung, colorectal, and urothelial cancers. When assessing tumor and stromal segmentation, Lunit SCOPE IO showed high concordance with pathologist assessments based on traditional immunohistochemistry (Spearman\u2019s correlation coefficients of 0.91 and 0.86). Threshold calibration improved alignment between the AI-based and pathologist scoring of inflamed, excluded, and desert immune phenotypes and improved its reliability and reproducibility. These results position Lunit SCOPE IO as a scalable solution for immune profiling, reducing reliance on additional IHC staining and enabling consistent analysis of the tumor immune microenvironment in both research and clinical practice.<\/p>\n

Lunit also introduced new data showcasing the utility of Lunit SCOPE uIHC, the company\u2019s AI-powered quantitative IHC platform, in mapping spatial interactions between tumor-infiltrating lymphocytes (TILs) and 74 membrane-specific protein targets currently in development for antibody-based therapies such as antibody-drug conjugates (ADCs) and bispecific T-cell engagers (BiTEs). Analyzing over 47,000 IHC images across 34 cancer types, the study revealed that while most protein targets showed decreased TIL density within expression regions, select proteins such as PD-L1 and TNFRSF4, displayed positive spatial correlation with lymphocyte infiltration. Notably, FGFR4 expression was linked to increased intra-tumoral lymphocytes in colorectal, non-squamous lung, and uterine cancers, suggesting its potential as a BiTE target. The findings demonstrate how Lunit SCOPE uIHC can integrate spatial immune context into early drug discovery workflows, accelerating the identification and validation of therapeutic targets.<\/p>\n

In another research, Lunit presented new data confirming the predictive power of AI-based spatial profiling in MET-mutated non-small cell lung cancer (NSCLC), demonstrating how AI-powered image-based profiling can uncover immunologically active subtypes within cancers.<\/p>\n

\u201cAt SITC 2025, we\u2019re showcasing how our digital pathology AI, the Lunit SCOPE suite, can bridge research and real-world clinical practice,\u201d said Brandon Suh, CEO of Lunit. \u201cFrom identifying immunotherapy-responsive subtypes to guiding antibody-based drug discovery, our AI technology is redefining how we understand and target the tumor\u2013immune interface. Collaborations like ours with CellCarta are key to unlocking the full potential of this transformation.\u201d<\/p>\n

Lunit\u2019s featured studies at SITC 2025 include:<\/strong><\/p>\n